Poppers - The Euphoric Wave of the Future
Poppers are a relatively new product to the Legal Party Drug Market, EDM scenes, Raves, House & Trance music largely due to the various dance trends and need for (1) energy (to T-step and Shuffle all night) & (2) they feel great (similar to MDMA but no crash or negative side effects). Whilst raves have been around for nearly 40 years, our proprietary blend of Natural ingredients have been around for centuries, early use dates back to Hunter-Gatherer societies. These days, it seems everyone is looking for something to take the edge off. Lately, the trends are leaning toward all-natural options over manufactured drugs. As an herbal remedy and natural mood booster, kanna, or Sceletium tortuosum, is a succulent plant native to South Africa that's served a healing, social, and spiritual purpose for thousands of years. Kanna has been gaining a lot of attention recently for being a less-risky alternative for party drugs because it has been reported as having a blissful effect on users.
Are Poppers a gay (lgbtq) street drug you inhale? - NOPE! Not ours, we liked the brand name and thought we would put a healthy spin on it. poppers are for everyone from every orientation - Out with the old in with the new!
What do Poppers do? People have said they’re a lighter version of MDMA with the same energetic rush as cocaine without jitters, a crash, addiction, or harmful effects on brain function.
What is Kanna? Sceletium tortuosum (L.) N.E.Br. (Mesembryanthemaceae), commonly known as kanna or kougoed, is an effective indigenous medicinal plant in South Africa, specifically to the native San and Khoikhoi tribes. Today, the plant has gained strong global attraction and reputation due to its capabilities to promote a sense of well-being by relieving stress with calming effects. Historically, the plant was used by native San hunter-gatherers and Khoi people to quench their thirst, fight fatigue, and for healing, social, and spiritual purposes. Various studies have revealed that extracts of the plant have numerous biological properties and isolated alkaloids of Sceletium Tortuosum are currently being used as dietary supplements for medicinal purposes and food. Furthermore, current research has focused on the commercialization of the plant because of its treatment in clinical anxiety and depression, psychological and psychiatric disorders, improving mood, and promoting relaxation and happiness. In addition, several studies have focused on the isolation and characterization of various beneficial bioactive compounds, including alkaloids from the Sceletium Tortuosum plant. Sceletium was reviewed more than a decade ago and new evidence has been published since 2008, substantiating an update on this South African botanical asset. Thus, this review provides an extensive overview of the biological and pharmaceutical properties of Sceletium Tortuosum as well as the bioactive compounds with an emphasis on antimicrobial, anti-inflammatory, antioxidant, antidepressant, anxiolytic, and other significant biological effects. There is a need to critically evaluate the bioactivities and responsible bioactive compounds, which might assist in reinforcing and confirming the significant role of Kanna in the promotion of healthy well-being in these stressful times.
"Historically”, Kanna forms part of the traditional practices of South Africa's first people, Khoisan," says clinical psychologist Vincenzo Sinisi, SAPA, HPCSA, founder of Therapy Route. "The Khoisan populated parts of what is now South Africa even before the African people considered indigenous to the region today did." It was typically consumed as a pinch of ground-up fermented plant matter and held under the tongue or chewed before swallowing. Today, extracts, tea, and supplements are available for easier ingestion. The Western world, and its mental health professionals in particular, are taking an interest in Kanna thanks to its calming and mind-clearing properties, which can work wonders for people dealing with anxiety and depression. In the brain, Kanna naturally bolsters serotonin reuptake and strengthens the mechanisms of attention and memory, effectively reducing stress, boosting mood, and promoting cognitive function.
I strongly support that this supplement is being used as an alternative to other party drugs. People are likely to experience similar euphoria effects without adverse effects on their health.
— MONIKA WASSERMANN, MD
Being from South Africa himself, Sinisi is familiar with Kanna's benefits through his own use and reports from patients. "When it works, it works without question," Sinisi says. "Roughly two hours after consumption, people feel markedly calmer, more content, and happier. The world feels like all is as it should be, and life seems worthwhile."
However, he notes that research is limited and studies are typically small or animal-based. One small proof-of-concept study suggests that kanna supplements enhance cognitive function and even have the potential to treat early stages of Alzheimer's disease.3
Wassermann warns against taking Kanna when also taking MAO inhibitors, MDMA, 5HTP, and/or SSRI antidepressants. The combination can rapidly increase your serotonin levels and lead to fever, shivering, elevated heart rate, or even death in severe cases. Of course, more research is needed to truly understand the safety and potential of Kanna. "Sure, it has been used in traditional practices for a long time," Sinisi says. "Still, this use was regulated by cultural norms that may not mirror recreational use."
Chiu S, Raheb H, Terpstra K, et al. Exploring Zembrin extract derived from South African plant, Sceletium Tortuosum in targeting cAMP-driven phosphodiesterase (PDE) signaling in Alzheimer's disease: Synthesis of evidence. Int J Ment Health Psychiatry. 2015;1(2). doi:10.4172/2471-4372.1000104
Mitragyna Speciosa, more commonly known as kratom, is a plant native to Southeast Asia, the leaves of which have been used traditionally as a stimulant, analgesic, and treatment for opioid addiction. Recently, growing use of the plant in the United States and concerns that kratom represents an uncontrolled drug with potential abuse liability, have highlighted the need for more careful study of its pharmacological activity. The major active alkaloid found in kratom, mitragynine, has been reported to have opioid agonist and analgesic activity in vitro and in animal models, consistent with the purported effects of kratom leaf in humans. However, preliminary research has provided some evidence that mitragynine and related compounds may act as atypical opioid agonists, inducing therapeutic effects such as analgesia, while limiting the negative side effects typical of classical opioids. Here we report evidence that an active metabolite plays an important role in mediating the analgesic effects of mitragynine. We find that mitragynine is converted in vitro in both mouse and human liver preparations to the much more potent mu-opioid receptor agonist 7-hydroxymitragynine and that this conversion is mediated by cytochrome P450 3A isoforms. Further, we show that 7-hydroxy mitragynine is formed from mitragynine in mice and that brain concentrations of this metabolite are sufficient to explain most or all of the opioid-receptor-mediated analgesic activity of mitragynine. At the same time, mitragynine is found in the brains of mice at very high concentrations relative to its opioid receptor binding affinity, suggesting that it does not directly activate opioid receptors. The results presented here provide a metabolism-dependent mechanism for the analgesic effects of mitragynine and clarify the importance of the route of administration for determining the activity of this compound. Further, they raise important questions about the interpretation of existing data on mitragynine and highlight critical areas for further research in animals and humans. Kratom, Kanna, 7-OH, hydroxymitragynine (7-Hydroxymitragynine Is an Active Metabolite of Mitragynine and a Key Mediator of Its Analgesic Effects).
