What does 7-hydroxymitragynine do?

Pharmacology. 7-Hydroxymitragynine, like mitragynine, appears to be a mixed opioid receptor agonist/antagonist, acting as a partial agonist at μ-opioid receptors and as a competitive antagonist at δ- and κ-opioid receptors. Evidence suggests that 7-OH in very high doses could be more potent than both mitragynine and morphine, which is why it’s growing among recovering opioid addicts, people suffering with extreme physical pain, people suffering from depression (in small proprietary doses).

7-OH is our carefully extracted kratom molecule, responsibly blended for a perfect dose of exactly what you need. No more No less, No fillers, No synthetics, No Problems! As enthusiasts and researchers delve further into the world of Kratom, it is becoming evident that Mitragynine and 7-Hydroxymitragynine hold the key to wellness. Their intricate interactions with the body pave the way for potential therapeutic applications, promising benefits for those seeking relief from discomfort and an enhanced sense of well-being.

Mitragyna Speciosa is a botanical name for one of the world’s most popular dietary supplements, Kratom. Kratom has its origins in South Asian countries like Vietnam, Indonesia, Malaysia, Thailand, Papua New Guinea, and Borneo among others. For thousands of years, this dietary supplement has been used for medicinal purposes, treating several medical conditions such as diarrhea, depression, soothing pain, enhancing moods, easing anxiety, helping with withdrawal symptoms from opioids, boosting one’s energy, and many more benefits. All, these health benefits derived either from its extracts or leaves are due to the presence of two major alkaloids: 7-Hydroxymitragynine(7ohm) and: Mitragynine.

Today kratom has been misunderstood by FDA and DEA because it communicates with opioid receptors in the brain. But Kratom belongs to the Rubiaceae family, as does coffee it’s nonaddictive and distinct from classical opioids such as (heroin, cocaine, OxyContin, Vicodin, and morphine). Thus kratom and coffee have similar properties such as stimulation, the elevation of moods, and energizing properties among other similarities.

Now that kratom has become the best alternative medication for pharmaceutical drugs which have not just become too expensive but also have severe side effects, we are here to help with 7-OH.

While mitragynine generally makes up about two-thirds of Kratom’s entire alkaloid content, 7-OH is still a notable component. Despite taking up an average of less than 0.05% of the dried leaf mass, 7-Hydroxymitragynine has its own crucial interactions with the body, coupling with the aforementioned alkaloid to partially agonize particular receptors and accompanying mitragynine as a G protein-biased agonist of the MOR.

Even though 7-OH is technically more potent than mitragynine, its limited concentrations within Kratom initially caused scientists to believe it was insufficient to induce any happiness or relaxation effects. That said, existing literature shows that the alkaloid seems to be formed from mitragynine in the body, with tests showing decreases in mitragynine at the same rate as 7-OH increases. Through this scientific research and anecdotal evidence, we gain valuable insights into the potential of these alkaloids, offering a deeper understanding of Kratom’s effects.